It has always
been understood by the profession that the births of the Royal children in all instances have been unattended by any peculiar or untoward circumstances. Intense astonishment, therefore, has
been excited throughout the profession by the rumor that her Majesty during her last labor was placed under the influence of chloroform, an agent which has unquestionably
caused instantaneous death in a considerable number of cases. Doubts on this subject cannot exist. In several of the fatal examples persons in their usual health expired while the process of inhalation was proceeding, and the deplorable catastrophes were clearly and indisputably referable to the poisonous action of chloroform, and to that cause alone.
One hundred and three years after chloroform had been administered by Dr. John Snow at the births of Prince Leopold and Princess Beatrice, British anesthetist William Stanley Sykes (1894–1961) published his book, Essays on the First Hundred Years of Anaethesia. In it he presents his views on the reaction of The Lancet editor Thomas Wakely to the use of chloroform by Snow at the birth of Prince Leopold. Notice Sykes mention of the distiction between analgesia which refers to pain relief without loss of consciousness, versus anesthesia which is loss of physical sensation, sometimes including a loss of consciousness.